Los Playoffs de la National Football League para la temporada 2010 terminarán con la disputa de la Super Bowl XLV el 6 de Febrero de 2011 en el Cowboys Stadium en Arlington, Texas. El Wild Card Weekend se jugará el 8 y el 9 de Enero, los Divisional Playoffs el 15 y el 16 de Enero, y los Conference Championships tendrán lugar el 23 de Enero.

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Equipos clasificados:

Playoff seeds
Seed	AFC	NFC
1	New England Patriots (East winner)	Atlanta Falcons (South winner)
2	Pittsburgh Steelers (North winner)	Chicago Bears (North winner)
3	Indianapolis Colts (South winner)	Philadelphia Eagles (East winner)
4	Kansas City Chiefs (West winner)	Seattle Seahawks (West winner)
5	Baltimore Ravens	New Orleans Saints
6	New York Jets	Green Bay Packers

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Emparejamientos:

	January 8 – Lucas Oil Stadium					January 16 – Gillette Stadium
	6	N.Y. Jets	17
						6	N.Y. Jets	28
	3	Indianapolis	16								January 23 – Heinz Field
						1	New England	21
						AFC
	January 9 – Arrowhead Stadium										6	N.Y. Jets	19
						January 15 – Heinz Field
											2	Pittsburgh	24
	5	Baltimore	30								AFC Championship
						5	Baltimore	24
	4	Kansas City	7													February 6 – Cowboys Stadium
						2	Pittsburgh	31
	Wild Card Playoffs
						Divisional Playoffs
	January 9 – Lincoln Financial Field															2	Pittsburgh	-
						January 15 – Georgia Dome
																6	Green Bay	-
	6	Green Bay	21													Super Bowl XLV
						6	Green Bay	48
	3	Philadelphia	16								January 23 – Soldier Field
						1	Atlanta	21
						NFC
	January 8 – Qwest Field										6	Green Bay	21
						January 16 – Soldier Field
											2	Chicago	14
	5	New Orleans	36								NFC Championship
						4	Seattle	24
	4	Seattle	41
						2	Chicago	35

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